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Relapsed Classic E Cadherin CDH1 Mutated Invasive Lobular

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Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) Drives .

Background. Most breast cancers depend on estrogenic growth stimulation. Functional genetic screenings in in vitro cell models have identified genes, which override growth suppression induced by anti-estrogenic drugs like tamoxifen. Using that approach, we have previously identified Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) as a mediator of cell proliferation and tamoxifen-resistance.

James X. Sun - Google Scholar Citatio

Relapsed classic E-Cadherin (CDH1)–mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations JS Ross, K Wang, CE Sheehan, AB Boguniewicz, G Otto, SR Downing, ... Clinical cancer research 19 (10), 2668-2676 , 2013

Doron Lipson - Vice President, Product Development and .

加入领英 个人简介 Strategic, hands-on leader with strong background in genomic application development. • Over 15 years of experience in developing analytical and clinical ...

Comprehensive Molecular Portraits of Invasive Lobular .

The discohesive phenotype is due to dysregulation of cell-cell adhesion, primarily driven by lack of E-cadherin (CDH1) protein expression observed in ∼90% of ILCs (McCart Reed et al., 2015, Morrogh et al., 2012). This feature is the ILC hallmark, and immunohistochemistry (IHC) scoring for CDH1 expression is often used to discriminate between ...

Comprehensive Molecular Portraits of Invasive Lobular .

The discohesive phenotype is due to dysregulation of cell-cell adhesion, primarily driven by lack of E-cadherin (CDH1) protein expression observed in ∼90% of ILCs (McCart Reed et al., 2015, Morrogh et al., 2012). This feature is the ILC hallmark, and immunohistochemistry (IHC) scoring for CDH1 expression is often used to discriminate between ...

Loss of function of NF1 is a mechanism of acquired .

Introduction Invasive lobular breast cancer (ILC) is a distinct clinicopathological entity with relatively unique biologic behavior as compared with invasive ductal carcinoma (IDC). ILC carry a distinct morphologic phenotype which is linked to the genomic inactivation of e-cadherin as the sine qua non of this disease.

Mutations in the Kinase Domain of the HER2/ERBB2 Gene .

The HER2 (official name ERBB2) gene encodes a membrane receptor in the epidermal growth factor receptor family amplified and overexpressed in adenocarcinoma. Activating mutations also occur in several cancers. We report mutation analyses of the HER2 kinase domain in 7497 histologically diverse cancers. Forty-five genes, including the kinase domain of HER2 with HER2 IHC and dual in situ ...

Invasive lobular carcinoma cell lines are characterized by .

Invasive lobular carcinoma (ILC) is a histologic subtype of breast cancer that is frequently associated with favorable outcomes, as approximately 90% of ILC express the estrogen receptor (ER). However, recent retrospective analyses suggest that patients with ILC receiving adjuvant endocrine therapy may not benefit as much as patients with invasive ductal carcinoma.

Relapsed classic E-cadherin (CDH1)-mutated invasive lobular .

Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. Clin Cancer Res 2013 May 15;19(10 ...

Relapsed classic E-cadherin (CDH1) mutated invasive .

Relapsed classic E-cadherin (CDH1) mutated invasive lobular breast cancer demonstrates a high frequency of HER2 (ERBB2) gene mutations NBC 180 - A partir d'échantillons tumoraux prélevés sur 22 patientes atteintes d'un carcinome lobulaire invasif

Breast Cancer Topic: HER2- with ERBB2 mutati

Relapsed Classic E-Cadherin (CDH1)-Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 (ERBB2) Gene Mutations. ... A clinical case of invasive lobular breast carcinoma with ERBB2 and CDH1 mutations presenting a dramatic response to anti-HER2-directed therapy.

Oncogenic Alterations in ERBB2/HER2 Represent Potential .

Oncogenic Alterations in ERBB2/HER2 Represent Potential Therapeutic Targets Across Tumors From Diverse Anatomic Sites of Origin ... Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 ... Mixed Invasive Ductal and Lobular Carcinoma of the Breast: Prognosis and the Importance of Histologic ...

Dr. Jeffrey Ross, Pathologist in Albany, NY | US News Docto

Dr. Jeffrey Ross is a Pathologist in Albany, NY. ... Relapsed Classic E-Cadherin (CDH1)-Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 (ERBB2) Gene Mutations ...

Relapsed classic E-Cadherin (CDH1)-mutated invasive .

Relapsed classic E-Cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations Article (PDF Available) in Clinical Cancer Research 19(10) · April ...

Breast Cancer Topic: Stage IV ILC -- Lets's Share Research .

Only about 10% of breast cancer cases are Invasive Lobular Carcinoma. It is an understudied type of breast cancer. Most of the research does not look at ILC separately, despite evidence that ILC is biologically different from IDC. ... Relapsed Classic E-Cadherin (CDH1)-Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 (ERBB2 ...

Publications Authored by John A Curran | PubFac

Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. Authors: Jeffrey S Ross Kai Wang Christine E Sheehan Ann B Boguniewicz Geoff Otto Sean R Downing James Sun Jie He John A Curran Siraj Ali Roman Yelensky Doron Lipson Gary Palmer Vincent A Miller Philip J Stephens.

CDH1) mutated invasive lobular breast cancer demonstrates .

1 Relapsed classic E-cadherin (CDH1) mutated invasive lobular breast cancer demonstrates a high frequency of HER2 (ERBB2) gene mutations Jeffrey S Ross1,2, Kai Wang2, Christine E Sheehan1, Ann B Boguniewicz1, Geoff Otto2, Sean R Downing2, James Sun2, Jie He2, John A Curran2, Siraj Ali2, Roman Yelensky2, Doron Lipson2, Gary Palmer2, Vincent A ...

Dr. Christine Sheehan, Pediatrician in Voorhees, NJ | US .

Dr. Christine Sheehan is a pediatrician in Voorhees, ... Relapsed Classic E-Cadherin (CDH1)-Mutated Invasive Lobular Breast Cancer Shows a High Frequency of HER2 (ERBB2) Gene Mutations ...