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Great care is therefore required in interpreting the results of binding studies with radioactive ligands and the criteria of saturability and specificity must be fulfilled before binding sites can be equated with receptor recognition sites [91,92].

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An example of the necessity for the change of the attitudes to drug quality involves the case of one of the most classical drugs, aspirin (1). Its quality has been characterised in the pharmacopoeias (old and new revisions alike) by titrimetric assay (saponi®cation by sodium hydroxide and back titration of the uncomsumed base).

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Clin Lab Med 28 (2008) xiii–xv Preface Kristen K. Reynolds, PhD Roland Valdes, Jr, PhD, FACB Guest Editors The serie...

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Identification and Determination of Impurities in Drugs .

An example of the necessity for the change of the attitudes to drug quality involves the case of one of the most classical drugs, aspirin (1). Its quality has been characterised in the pharmacopoeias (old and new revisions alike) by titrimetric assay (saponi®cation by sodium hydroxide and back titration of the uncomsumed base).

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