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Role of lubricin and boundary lubrication in the

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The biology of Lubricin: Near frictionless joint motion .

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

Friction force microscopy of lubricin and hyaluronic acid .

Lubricin and hyaluronic acid (HA) are two constituents of synovial fluid thought to have a role in boundary lubrication. Boundary lubrication3 is accomplished by lubricants adsorbed or bonded to the apposing bearing surfaces and is operative where surfaces come into contact.4 It is one of the multiple

Role of lubricin and boundary lubrication in the .

Lubricin, a mucinous glycoprotein produced by synovial cells and superficial zone chondrocytes (11, 14), provides lubrication in the boundary mode . Boundary lubrication dominates during periods of high load and low velocity, when the lubricant film layer is thinner than the surface roughness .

PNAS揭示关节炎防治新方法 - 生物

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Osteoarthritis is a complex disease involving the mechanical breakdown of articular ...

Role of lubricin and boundary lubrication in the .

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated ...

Regulation of lubricin for functional cartilage tissue .

Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and ...

Lubricin: New Promise for Joint-Preserving Therapy .

The boundary mode of the synovial joint is lubricated during periods of low sliding speed (less than 0.3 mm/sec) 1 and high physiologic loads (approaching 5 mPa) 2 by hyaluronic acid and lubricin, which prevents the pressurized joint surfaces from adhering to each other. 3 Boundary lubricants comprise a layer that is less than the height of the asperities (roughness) of the joint surfaces. 4,7,8

Lubricin: a novel potential biotherapeutic approaches for .

Therefore, a treatment with lubricin which would protect cartilage in vivo would be desirable. This article reviews recent findings with regard to the possible role of lubricin in the progression of OA, and further discusses lubricin as a novel potential biotherapeutic approaches for the treatment of OA.

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

Stimulation of Superficial Zone Protein/Lubricin/PRG4 by .

Superficial zone protein (SZP), also known as lubricin and proteoglycan 4 (PRG4), plays an important role in the boundary lubrication of articular cartilage and is regulated by transforming growth factor (TGF)-β.

Boundary Lubrication - an overview | ScienceDirect Topi

Boundary lubrication involves a single monolayer of lubricant molecules, which are absorbed onto each of the bearing surfaces. This avoids surface wear by impeding the direct contact of surfaces (Hsu and Gates, 2000). The synovial fluid constituent responsible for the boundary lubrication is a specific glycoprotein, termed ‘lubricin’.

Biotribological Assessment for Artificial Synovial Joints .

Biotribological Assessment for Artificial Synovial Joints: The Role of Boundary Lubrication Doctorate of Philosophy in Biomedical Engineering by LORNE R GALE, BE(Mech, Hons) Thesis submitted for the degree of Doctor of Philosophy, School of Engineering Systems, Institute of Health and Biomedical Innovation (IHBI),

Regulation of lubricin for functional cartilage tissue .

Structure and functional role of lubricin. Lubricin, a product of the proteoglycan 4 (PRG4) gene, is highly expressed by synoviocytes and superficial zone chondrocytes [].Lubricin, generally known as a proteoglycan, is a glycoprotein that functions as a critical boundary lubricant for articular cartilage and normally isolated from synovial fluid [].

The role of lubricin in normal and pathological joint tissue: a contemporary revi

The aim of this article was to critically review the literature about lubricin and its involvement in normal and pathological joint tissue. In particular, our research focussed on new therapeutic approaches for the treatment of osteoarthritis related to lubricin. We reviewed the literature regarding lubricin expression.

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912; bEmergency Medicine Research Laboratory, Department of Emergency Medicine ...

Galectin-3 Binds to Lubricin and Reinforces the .

Effective boundary lubrication by lubricin is dependent upon both its ability to adsorb to articular cartilage 11,12 and the presence of O-linked β(1–3)Gal-GalNAc oligosaccharides 13; however ...

The role of lubricin in normal and pathological joint .

of lubricin, including lubrication and cytoprotection. Lubricin plays an important role in articular joint physiology, and the loss of accumu-lation of lubricin may be a factor in the pathology of osteoarthritis (OA) (Figure 1). Therefore, a recent study8 demonstrated that recombi-nant lubricin has a role in chondro-protection in an animal OA model

Molecular Aspects of Boundary Lubrication by Human .

Lubricin (LUB) is a glycoprotein of the synovial cavity of human articular joints, where it serves as an antiadhesive, boundary lubricant, and regulating factor for the cartilage surface. It has been proposed that these properties are related to the presence of a long, extended, heavily glycosylated and highly hydrated mucinous domain in the central part of the LUB molecule.

Lubricin: New Promise for Joint-Preserving Therapy .

The boundary mode of the synovial joint is lubricated during periods of low sliding speed (less than 0.3 mm/sec) 1 and high physiologic loads (approaching 5 mPa) 2 by hyaluronic acid and lubricin, which prevents the pressurized joint surfaces from adhering to each other. 3 Boundary lubricants comprise a layer that is less than the height of the asperities (roughness) of the joint surfaces. 4,7,8

Supramolecular synergy in the boundary lubrication of .

Boundary lubrication measured in the SFB arises from dissipation at the slip plane between the intimately contacting boundary layers ... The role of lubricin in the mechanical behavior of ...